Memory CD8 T-cell compartment grows in size with immunological experience

Vaiva Vezys, Andrew Yates, Kerry A. Casey, Gibson Lanier, Rafi Ahmed, Rustom Antia and David Masopust ()
Additional contact information
Vaiva Vezys: University of Minnesota, Minneapolis, Minnesota 55455, USA
Andrew Yates: Emory University, Atlanta, Georgia 30322, USA
Kerry A. Casey: University of Minnesota, Minneapolis, Minnesota 55455, USA
Gibson Lanier: Emory Vaccine Center, Emory University School of Medicine, and,
Rafi Ahmed: Emory Vaccine Center, Emory University School of Medicine, and,
Rustom Antia: Emory University, Atlanta, Georgia 30322, USA
David Masopust: University of Minnesota, Minneapolis, Minnesota 55455, USA

Nature, 2009, vol. 457, issue 7226, 196-199

Abstract: Gaining from the experience Repeated exposure to pathogens and the generation of memory CD8+ T cells tasked to kill that pathogen is thought to result in attrition of the pre-existing memory T cell pool to keep the overall size of the memory compartment constant. But new work in mice shows that the size of the memory CD8+ T-cell compartment increases after immunization, and that the generation of new memory CD8+ T cells does not significantly reduce the number of pre-existing memory CD8+ T cells. The discovery that the number of CD8+ T-cell cells in the mammalian host can adapt according to immunological experience could be important for the production of vaccines, since it may be possible to induce specific immune responses that require a high frequency of CD8+ T cells without impairing pre-existing immunities to other infections.

Date: 2009
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DOI: 10.1038/nature07486

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