Analysis of combinatorial cis-regulation in synthetic and genomic promoters

Jason Gertz, Eric D. Siggia and Barak A. Cohen ()
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Jason Gertz: Center for Genome Sciences, Washington University in Saint Louis School of Medicine, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
Eric D. Siggia: Center for Studies in Physics and Biology, The Rockefeller University, New York, New York 10021, USA
Barak A. Cohen: Center for Genome Sciences, Washington University in Saint Louis School of Medicine, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA

Nature, 2009, vol. 457, issue 7226, 215-218

Abstract: Gene promoters: expressing themselves Despite countless catalogues of genomic binding sites for transcription factors, predicting the expression of a gene purely based on its DNA sequence has remained very inaccurate. Gertz et al. present a general thermodynamic model that accurately captures the relationship between a gene promoter sequence, including weak, statistically undetectable regulatory sites, and its expression output. The work implies that chromatin plays a relatively minor role in directing gene expression and will facilitate rational genetic design in biotechnology and synthetic biology.

Date: 2009
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DOI: 10.1038/nature07521

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