Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis

Jiyun V. Kim, Silvia S. Kang, Michael L. Dustin () and Dorian B. McGavern ()
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Jiyun V. Kim: Program in Molecular Pathogenesis, Helen L. and Martin S. Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
Silvia S. Kang: The Scripps Research Institute, La Jolla, California 92037, USA
Michael L. Dustin: Program in Molecular Pathogenesis, Helen L. and Martin S. Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
Dorian B. McGavern: The Scripps Research Institute, La Jolla, California 92037, USA

Nature, 2009, vol. 457, issue 7226, 191-195

Abstract: Killer cells off duty Central nervous system infection of mice with lymphocytic choriomeningitis virus (LCMV) is a commonly used model for chronic viral disease. LCMV-specific cytotoxic T lymphocytes (CD8+ T cells) are involved in the condition, but their role in pathogenesis is unclear. The 'cell killing' activity of these cells might be expected to be part of the story, but a new study using two-photon fluorescence microscopy suggests this is not the case. Rather, cytotoxic T lymphocytes can be seen recruiting monocytes and neutrophils to the meninges at the blood–brain border. The blood vessels there become leaky and fatal seizures result. This raises new questions, including the mechanism of cell recruitment and how the cells produce such damage in meningitis, and suggests several new drug targets.

Date: 2009
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DOI: 10.1038/nature07591

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