Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis

Masako Kohyama, Wataru Ise, Brian T. Edelson, Peter R. Wilker, Kai Hildner, Carlo Mejia, William A. Frazier, Theresa L. Murphy and Kenneth M. Murphy ()
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Masako Kohyama: Department of Pathology and Immunology,
Wataru Ise: Department of Pathology and Immunology,
Brian T. Edelson: Department of Pathology and Immunology,
Peter R. Wilker: Department of Pathology and Immunology,
Kai Hildner: Department of Pathology and Immunology,
Carlo Mejia: Department of Pathology and Immunology,
William A. Frazier: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
Theresa L. Murphy: Department of Pathology and Immunology,
Kenneth M. Murphy: Department of Pathology and Immunology,

Nature, 2009, vol. 457, issue 7227, 318-321

Abstract: Red pulp macrophage formation Red pulp macrophages are a distinct subset of tissue macrophages found in the spleen, and are thought to be involved in removal of senescent red blood cells. Kohyama et al. this week show that Spi-C, a PU.1-related transcription factor, selectively controls the development of red pulp macrophages. Spi-C-deficient mice fail to phagocytose trapped red blood cells. This is the first report of a transcription factor controlling the development of a tissue macrophage subset, and provides an example of a disorder in iron homeostasis caused by the loss of a specific cell lineage.

Date: 2009
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DOI: 10.1038/nature07472

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