Transcription inactivation through local refolding of the RNA polymerase structure

Georgiy A. Belogurov, Marina N. Vassylyeva, Anastasiya Sevostyanova, James R. Appleman, Alan X. Xiang, Ricardo Lira, Stephen E. Webber, Sergiy Klyuyev, Evgeny Nudler, Irina Artsimovitch () and Dmitry G. Vassylyev ()
Additional contact information
Georgiy A. Belogurov: The Ohio State University, 484 West 12th Avenue, Columbus, Ohio 43210, USA
Marina N. Vassylyeva: University of Alabama at Birmingham, Schools of Medicine and Dentistry, 720 20th Street South, Birmingham, Alabama 35294, USA
Anastasiya Sevostyanova: The Ohio State University, 484 West 12th Avenue, Columbus, Ohio 43210, USA
James R. Appleman: Anadys Pharmaceuticals, Inc., 3115 Merryfield Row, San Diego, California 92121, USA
Alan X. Xiang: Anadys Pharmaceuticals, Inc., 3115 Merryfield Row, San Diego, California 92121, USA
Ricardo Lira: Anadys Pharmaceuticals, Inc., 3115 Merryfield Row, San Diego, California 92121, USA
Stephen E. Webber: Anadys Pharmaceuticals, Inc., 3115 Merryfield Row, San Diego, California 92121, USA
Sergiy Klyuyev: University of Alabama at Birmingham, Schools of Medicine and Dentistry, 720 20th Street South, Birmingham, Alabama 35294, USA
Evgeny Nudler: New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Irina Artsimovitch: The Ohio State University, 484 West 12th Avenue, Columbus, Ohio 43210, USA
Dmitry G. Vassylyev: University of Alabama at Birmingham, Schools of Medicine and Dentistry, 720 20th Street South, Birmingham, Alabama 35294, USA

Nature, 2009, vol. 457, issue 7227, 332-335

Abstract: Myxopyronins on target A crystal structure of the antibiotic myxopyronin bound to bacterial RNA polymerase (RNAP) reveals insights into how the antibiotic targets the formation of the pre-catalytic transcription initiation complex and the mechanism of open complex formation. The myxopyronins are possibly the first structurally characterized class of antibiotics known to act on this decisive step in gene expression control.

Date: 2009
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DOI: 10.1038/nature07510

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