Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis

Samir M. Hamdan, Joseph J. Loparo, Masateru Takahashi, Charles C. Richardson and Antoine M. van Oijen ()
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Samir M. Hamdan: Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Joseph J. Loparo: Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Masateru Takahashi: Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Charles C. Richardson: Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Antoine M. van Oijen: Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA

Nature, 2009, vol. 457, issue 7227, 336-339

Abstract: DNA replication: a sense of direction During DNA replication, both strands are processed simultaneously, but they have opposite polarities. To explain how replication machinery that is unidirectional can accomplish this feat, a trombone model has been proposed. In this model, the lagging strand forms a loop that allows it to enter the replication machinery in the same direction as the leading strand. In this study, Hamdan et al. use single-molecule techniques to examine this process in real time. They find that this loop is reinitiated with the priming of every Okazaki fragment, and released when the previous fragment is encountered by the replisome.

Date: 2009
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DOI: 10.1038/nature07512

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