A tunable synthetic mammalian oscillator

Marcel Tigges, Tatiana T. Marquez-Lago, Jörg Stelling () and Martin Fussenegger ()
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Marcel Tigges: ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland
Tatiana T. Marquez-Lago: ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland
Jörg Stelling: ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland
Martin Fussenegger: ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland

Nature, 2009, vol. 457, issue 7227, 309-312

Abstract: An around-the-clock synthetic gene circuit Synthetic gene circuits producing oscillating outputs have been developed only in bacteria, and it has been difficult to make them reliable even there. Tigges et al. have now developed a synthetic sense–antisense circuit in mammalian cells that produces autonomous, self-sustained and tunable cyclic gene expression. This synthetic mammalian clock will be of use in the study of oscillations in mammalian cells, and may improve our understanding of the circadian clock and associated pathologies.

Date: 2009
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DOI: 10.1038/nature07616

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