A core gut microbiome in obese and lean twins

Peter J. Turnbaugh, Micah Hamady, Tanya Yatsunenko, Brandi L. Cantarel, Alexis Duncan, Ruth E. Ley, Mitchell L. Sogin, William J. Jones, Bruce A. Roe, Jason P. Affourtit, Michael Egholm, Bernard Henrissat, Andrew C. Heath, Rob Knight and Jeffrey I. Gordon ()
Additional contact information
Peter J. Turnbaugh: Center for Genome Sciences
Micah Hamady: Department of Computer Science
Tanya Yatsunenko: Center for Genome Sciences
Brandi L. Cantarel: CNRS, UMR6098, Marseille, France
Alexis Duncan: Washington University School of Medicine, St Louis, Missouri 63108, USA
Ruth E. Ley: Center for Genome Sciences
Mitchell L. Sogin: Josephine Bay Paul Center, Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
William J. Jones: Environmental Genomics Core Facility, University of South Carolina, Columbia, South Carolina 29208, USA
Bruce A. Roe: University of Oklahoma, Norman, Oklahoma 73019, USA
Jason P. Affourtit: 454 Life Sciences, Branford, Connecticut 06405, USA
Michael Egholm: 454 Life Sciences, Branford, Connecticut 06405, USA
Bernard Henrissat: CNRS, UMR6098, Marseille, France
Andrew C. Heath: Washington University School of Medicine, St Louis, Missouri 63108, USA
Rob Knight: University of Colorado, Boulder, Colorado 80309, USA
Jeffrey I. Gordon: Center for Genome Sciences

Nature, 2009, vol. 457, issue 7228, 480-484

Abstract: Obese and lean microbiota The many 'friendly' microbes that inhabit the human gut have been implicated in numerous health-related issues, in particular those involving digestion and susceptibility to infection. A study of the faecal microbial communities of pairs of adult female twins, selected to include 'lean' and 'obese' individuals, reveals some similarities between the human gut microbiomes among family members, but each person's gut microbial community varies in the specific bacterial lineages present. There was a wide array of shared microbial genes among individuals, comprising an identifiable 'core microbiome' at the gene, rather than at the microbial species level. This core includes many novel genes for carbohydrate metabolism, and deviations from this core are associated with the obese versus lean state.

Date: 2009
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DOI: 10.1038/nature07540

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