Endochondral ossification is required for haematopoietic stem-cell niche formation

Charles K. F. Chan (), Ching-Cheng Chen (), Cynthia A. Luppen, Jae-Beom Kim, Anthony T. DeBoer, Kevin Wei, Jill A. Helms, Calvin J. Kuo, Daniel L. Kraft and Irving L. Weissman
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Charles K. F. Chan: Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California, USA
Ching-Cheng Chen: Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California, USA
Cynthia A. Luppen: Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California, USA
Jae-Beom Kim: Stanford University, California, USA
Anthony T. DeBoer: Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California, USA
Kevin Wei: Stanford University, California, USA
Jill A. Helms: Stanford University, California, USA
Calvin J. Kuo: Stanford University, California, USA
Daniel L. Kraft: Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California, USA
Irving L. Weissman: Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California, USA

Nature, 2009, vol. 457, issue 7228, 490-494

Abstract: Haematopoietic stem cells: establishing a niche Chan et al. identify and prospectively isolate a progenitor cell population derived from mouse fetal limb skeletal elements that forms an ectopic haematopoietic stem cell (HSC) niche in vivo. When transplanted under the adult mouse kidney capsule, the cells recruit host-derived blood vessels, produce donor-derived ectopic bones, and generate a marrow cavity populated by host-derived long-term reconstituting HSCs. Niche generation was inhibited by the suppression of factors involved in endochondral ossification.

Date: 2009
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DOI: 10.1038/nature07547

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