Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

Aurelien Trompette, Senad Divanovic, Alberto Visintin, Carine Blanchard, Rashmi S. Hegde, Rajat Madan, Peter S. Thorne, Marsha Wills-Karp, Theresa L. Gioannini, Jerry P. Weiss and Christopher L. Karp ()
Additional contact information
Aurelien Trompette: Division of Molecular Immunology,
Senad Divanovic: Division of Molecular Immunology,
Alberto Visintin: University of Massachusetts Medical School, Worcester, Massachusetts 01606, USA
Carine Blanchard: Division of Allergy and Immunology,
Rashmi S. Hegde: and
Rajat Madan: Division of Molecular Immunology,
Peter S. Thorne: and
Marsha Wills-Karp: Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Theresa L. Gioannini: Inflammation Program, University of Iowa, Iowa City, Iowa 52241, USA
Jerry P. Weiss: Inflammation Program, University of Iowa, Iowa City, Iowa 52241, USA
Christopher L. Karp: Division of Molecular Immunology,

Nature, 2009, vol. 457, issue 7229, 585-588

Abstract: Mite allergen plays tricks House dust mites (Dermatophagoides spp.) are a common cause of allergy, known to trigger asthma attacks. The main dust-mite allergen, Der p 2, is found in high concentrations in mite faecal pellets. Der p 2 has structural homology with a component of the Toll-like-receptor signalling complex, and now that homology has been implicated in the mechanism by which such a strong allergic response is provoked. Der p 2 is shown to mimic the function of a Toll-like receptor complex protein, acting as an 'auto-adjuvant' and in effect tricking the immune system into believing that it is facing a bacterial infection.

Date: 2009
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DOI: 10.1038/nature07548

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