WNT11 acts as a directional cue to organize the elongation of early muscle fibres

Jérôme Gros, Olivier Serralbo and Christophe Marcelle ()
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Jérôme Gros: Developmental Biology Institute of Marseille Luminy (IBDML), Université de la Méditerranée, CNRS UMR 6216, Campus de Luminy, case 907, 13288 Marseille Cedex 09, France
Olivier Serralbo: Developmental Biology Institute of Marseille Luminy (IBDML), Université de la Méditerranée, CNRS UMR 6216, Campus de Luminy, case 907, 13288 Marseille Cedex 09, France
Christophe Marcelle: Developmental Biology Institute of Marseille Luminy (IBDML), Université de la Méditerranée, CNRS UMR 6216, Campus de Luminy, case 907, 13288 Marseille Cedex 09, France

Nature, 2009, vol. 457, issue 7229, 589-593

Abstract: Muscle development: WNT11 gives direction How muscle fibres (myofibres) acquire their orientation during development is unknown. Gros et al. this week show that during early myogenesis, WNT11 plays an essential role in the oriented elongation of the myocytes. Furthermore, WNT11 mediates this effect through the evolutionary conserved planar cell polarity pathway (PCP), which is downstream of the WNT/β-catenin-dependent pathway. They show that a localized ectopic source of WNT11 can change the orientation of myocytes, indicating that WNT11 acts as a directional cue in this process. This study provides the first evidence that WNTs can act as instructive cues to regulate the PCP pathway in vertebrates.

Date: 2009
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DOI: 10.1038/nature07564

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