Enterotoxigenic Escherichia coli EtpA mediates adhesion between flagella and host cells

Koushik Roy, George M. Hilliard, David J. Hamilton, Jiwen Luo, Marguerite M. Ostmann and James M. Fleckenstein ()
Additional contact information
Koushik Roy: Department of Medicine,
George M. Hilliard: Department of Molecular Sciences,
David J. Hamilton: University of Tennessee Health Science Center, 956 Court Avenue, Memphis, Tennessee 38163, Tennessee, USA
Jiwen Luo: Department of Medicine,
Marguerite M. Ostmann: Research Service,
James M. Fleckenstein: Department of Medicine,

Nature, 2009, vol. 457, issue 7229, 594-598

Abstract: E. coli vaccine targets Enterotoxigenic Escherichia coli is the most common cause of diarrhoea in developing countries and is the principal cause of traveller's diarrhoea. Adhesion to host cells is essential for the virulence of this and many other bacterial pathogens. A new adhesion mechanism has been identified in E. coli that relies on the secreted protein EtpA. The protein interacts with conserved regions of flagellin molecules at the tips of the bacterial flagella where it forms an adhesive molecular bridge between the bacterium and the host cell. This finding adds to the evidence that EtpA — and the conserved flagellin ligands —could be viable antigenic targets for vaccines against E. coli and other motile pathogens.

Date: 2009
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature07568 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:457:y:2009:i:7229:d:10.1038_nature07568

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07568

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().