Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

Liqin Zhu, Paul Gibson, D. Spencer Currle, Yiai Tong, Robert J. Richardson, Ildar T. Bayazitov, Helen Poppleton, Stanislav Zakharenko, David W. Ellison and Richard J. Gilbertson ()
Additional contact information
Liqin Zhu: Department of Developmental Neurobiology,
Paul Gibson: Department of Developmental Neurobiology,
D. Spencer Currle: Department of Developmental Neurobiology,
Yiai Tong: Department of Developmental Neurobiology,
Robert J. Richardson: Department of Developmental Neurobiology,
Ildar T. Bayazitov: Department of Developmental Neurobiology,
Helen Poppleton: Department of Developmental Neurobiology,
Stanislav Zakharenko: Department of Developmental Neurobiology,
David W. Ellison: Pathology and,
Richard J. Gilbertson: Department of Developmental Neurobiology,

Nature, 2009, vol. 457, issue 7229, 603-607

Abstract: Intestinal cancer: stem-cell destinies Inappropriate activation of the Wnt signalling pathway in intestinal stem cells causes them to become cancerous. Two papers in this issue help identify the cell type at the root of this cancer, which should in turn aid therapeutic design. Zhu et al. report that prominin 1, a surface protein found on both normal stem cells and cancer stem cells, is a marker for stem cells that are prone to neoplastic transformation. Barker et al. show that in cells expressing Lgr5, previously identified as a marker for intestinal stem cells, activation of Wnt signalling is sufficient to initiate tumour formation.

Date: 2009
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DOI: 10.1038/nature07589

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