A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

Marina Cella, Anja Fuchs, William Vermi, Fabio Facchetti, Karel Otero, Jochen K. M. Lennerz, Jason M. Doherty, Jason C. Mills and Marco Colonna ()
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Marina Cella: Washington University School of Medicine, St Louis, Missouri 63110, USA
Anja Fuchs: Washington University School of Medicine, St Louis, Missouri 63110, USA
William Vermi: Spedali Civili, University of Brescia
Fabio Facchetti: Spedali Civili, University of Brescia
Karel Otero: Washington University School of Medicine, St Louis, Missouri 63110, USA
Jochen K. M. Lennerz: Washington University School of Medicine, St Louis, Missouri 63110, USA
Jason M. Doherty: Washington University School of Medicine, St Louis, Missouri 63110, USA
Jason C. Mills: Washington University School of Medicine, St Louis, Missouri 63110, USA
Marco Colonna: Washington University School of Medicine, St Louis, Missouri 63110, USA

Nature, 2009, vol. 457, issue 7230, 722-725

Abstract: NK-22 cells: an anti-inflammatory role A previously unrecognized subset of human natural killer (NK) lymphocytes is reported. These 'NK-22' cells are selectively localized in tonsil and gut mucosa and, in contrast to conventional NK cells, are poorly cytotoxic and secrete little or no interferon. Rather, they specialize in the secretion of interleukin 22 (IL-22), IL-26 and leukaemia inhibitory factor, all of which have been implicated in the protection of epithelia. The properties of NK-22 cells are consistent with an anti-inflammatory response that may contribute to the maintenance of mucosal integrity.

Date: 2009
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DOI: 10.1038/nature07537

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