Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80

Boxun Lu, Yanhua Su, Sudipto Das, Haikun Wang, Yan Wang, Jin Liu and Dejian Ren ()
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Boxun Lu: University of Pennsylvania, 415 S. University Avenue, Philadelphia, Pennsylvania 19104, USA
Yanhua Su: University of Pennsylvania, 415 S. University Avenue, Philadelphia, Pennsylvania 19104, USA
Sudipto Das: University of Pennsylvania, 415 S. University Avenue, Philadelphia, Pennsylvania 19104, USA
Haikun Wang: University of Pennsylvania, 415 S. University Avenue, Philadelphia, Pennsylvania 19104, USA
Yan Wang: University of Pennsylvania, 415 S. University Avenue, Philadelphia, Pennsylvania 19104, USA
Jin Liu: University of Pennsylvania, 415 S. University Avenue, Philadelphia, Pennsylvania 19104, USA
Dejian Ren: University of Pennsylvania, 415 S. University Avenue, Philadelphia, Pennsylvania 19104, USA

Nature, 2009, vol. 457, issue 7230, 741-744

Abstract: Neuropetides: action via NALCN and UNC-80 Substance P is a neuropeptide that evokes slow excitation following activation of its cognate G-protein-coupled receptor. Lu et al. investigate the downstream pathway of substance P and show that it depends on Src family kinases rather than G-protein signalling. They also identify the target ion channel as the NALCN cation channel, which acts in complex with a cytosolic protein of unknown function, UNC-80.

Date: 2009
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DOI: 10.1038/nature07579

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