ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

Shigeru Oshima, Emre E. Turer, Joseph A. Callahan, Sophia Chai, Rommel Advincula, Julio Barrera, Nataliya Shifrin, Bettina Lee, Benjamin Yen, Tammy Woo, Barbara A. Malynn and Averil Ma ()
Additional contact information
Shigeru Oshima: University of California at San Francisco, 513 Parnassus Avenue, S-1057, San Francisco, California 94143-0451, USA
Emre E. Turer: University of California at San Francisco, 513 Parnassus Avenue, S-1057, San Francisco, California 94143-0451, USA
Joseph A. Callahan: University of California at San Francisco, 513 Parnassus Avenue, S-1057, San Francisco, California 94143-0451, USA
Sophia Chai: University of California at San Francisco, 513 Parnassus Avenue, S-1057, San Francisco, California 94143-0451, USA
Rommel Advincula: University of California at San Francisco, 513 Parnassus Avenue, S-1057, San Francisco, California 94143-0451, USA
Julio Barrera: University of California at San Francisco, 513 Parnassus Avenue, S-1057, San Francisco, California 94143-0451, USA
Nataliya Shifrin: University of California at San Francisco, 513 Parnassus Avenue, S-1057, San Francisco, California 94143-0451, USA
Bettina Lee: University of California at San Francisco, 513 Parnassus Avenue, S-1057, San Francisco, California 94143-0451, USA
Benjamin Yen: University of California at San Francisco, 513 Parnassus Avenue, S-1057, San Francisco, California 94143-0451, USA
Tammy Woo: University of California at San Francisco, 513 Parnassus Avenue, S-1057, San Francisco, California 94143-0451, USA
Barbara A. Malynn: University of California at San Francisco, 513 Parnassus Avenue, S-1057, San Francisco, California 94143-0451, USA
Averil Ma: University of California at San Francisco, 513 Parnassus Avenue, S-1057, San Francisco, California 94143-0451, USA

Nature, 2009, vol. 457, issue 7231, 906-909

Abstract: Ubiquitin sensors: vital role for ABIN-1 Oshima et al. this week show that ABIN-1 — a protein that interacts with the ubiquitin-editing enzyme A20 and is thought to negatively influence NF-κB signalling — is essential for life; without it, mice die during embryogenesis with fetal liver apoptosis and anaemia. However, this phenomenon appears unrelated to ABIN-1's role in NF-κB signalling. The authors show that ABIN-1 is ubiquitinated and as such binds to and interferes with components of the TNF-induced signalling complex, the so-called DISC. This prevents programmed cell death and allows proper development. This adds to the emerging role for non-degrading ubiquitin modifications in life and death cell-fate decisions.

Date: 2009
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DOI: 10.1038/nature07575

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