Calcium flickers steer cell migration

Chaoliang Wei (), Xianhua Wang, Min Chen, Kunfu Ouyang, Long-Sheng Song and Heping Cheng ()
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Chaoliang Wei: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
Xianhua Wang: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
Min Chen: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
Kunfu Ouyang: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
Long-Sheng Song: University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
Heping Cheng: Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University

Nature, 2009, vol. 457, issue 7231, 901-905

Abstract: Calcium leads the way Directional cell movement depends on an intracellular calcium gradient. In a study of migrating fibroblasts, Chaoliang Wei et al. have identified calcium flickers — high-calcium microdomains — as part of the mechanism that steers cells to their targets. The flickers are most active at the leading edge of migrating cells. In the presence of a chemotactic gradient, an asymmetric gradient of calcium flicker activity develops which promotes turning of cells towards the direction of the chemoattractant.

Date: 2009
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DOI: 10.1038/nature07577

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