The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage

Christophe Lancrin, Patrycja Sroczynska, Catherine Stephenson, Terry Allen, Valerie Kouskoff and Georges Lacaud ()
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Christophe Lancrin: Cancer Research UK Stem Cell Biology Group,
Patrycja Sroczynska: Cancer Research UK Stem Cell Biology Group,
Catherine Stephenson: Cancer Research UK Stem Cell Biology Group,
Terry Allen: Cancer Research UK Structural Cell Biology Group,
Valerie Kouskoff: Cancer Research UK Stem Cell Haematopoiesis Group, Paterson Institute for Cancer Research, University of Manchester, Wilmslow road, Manchester M20 4BX, UK
Georges Lacaud: Cancer Research UK Stem Cell Biology Group,

Nature, 2009, vol. 457, issue 7231, 892-895

Abstract: Blood lines How the blood system forms during embryonic development is a topic of intensive research, in part because of the potential importance of the process for regenerative medicine. Two main theories have emerged to explain the formation of the haematopoietic stem cells that eventually populate the adult born marrow. One idea is that the haematopoietic stem cell and the endothelial lineage arise independently from the mesoderm; the other is that some haematopoietic and endothelial lineages derive from a specialized progenitor called a haemangioblast. Three papers in this issue unify the two theories. Both are correct: the haemangioblast does generate haematopoietic cells, but via a haemogenic endothelium intermediate.

Date: 2009
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DOI: 10.1038/nature07679

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