Human occludin is a hepatitis C virus entry factor required for infection of mouse cells

Alexander Ploss, Matthew J. Evans, Valeriya A. Gaysinskaya, Maryline Panis, Hana You, Ype P. de Jong and Charles M. Rice ()
Additional contact information
Alexander Ploss: Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, 10065 USA
Matthew J. Evans: Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, 10065 USA
Valeriya A. Gaysinskaya: Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, 10065 USA
Maryline Panis: Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, 10065 USA
Hana You: Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, 10065 USA
Ype P. de Jong: Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, 10065 USA
Charles M. Rice: Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, 10065 USA

Nature, 2009, vol. 457, issue 7231, 882-886

Abstract: Hepatitis C: model answer The development of an effective vaccine and specific antiviral therapies against hepatitis C virus (HCV), a leading cause of liver disease, has been hampered by the lack of a convenient small animal model. With the identification of the gap junction protein occludin as the fourth and final key component of the hepatitis C virus cell-entry receptor, that elusive lab model may have come a step nearer. In addition to human occludin, viral infection of murine cells requires expression of the previously identified HCV entry factors CD81, scavenger receptor class B type I, and claudin-1.

Date: 2009
References: Add references at CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.nature.com/articles/nature07684 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:457:y:2009:i:7231:d:10.1038_nature07684

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07684

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().