Continuous single-cell imaging of blood generation from haemogenic endothelium

Hanna M. Eilken, Shin-Ichi Nishikawa and Timm Schroeder ()
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Hanna M. Eilken: Institute of Stem Cell Research, Helmholtz Center Munich—German Research Center for Environmental Health (GmbH)
Shin-Ichi Nishikawa: Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology
Timm Schroeder: Institute of Stem Cell Research, Helmholtz Center Munich—German Research Center for Environmental Health (GmbH)

Nature, 2009, vol. 457, issue 7231, 896-900

Abstract: Blood lines How the blood system forms during embryonic development is a topic of intensive research, in part because of the potential importance of the process for regenerative medicine. Two main theories have emerged to explain the formation of the haematopoietic stem cells that eventually populate the adult born marrow. One idea is that the haematopoietic stem cell and the endothelial lineage arise independently from the mesoderm; the other is that some haematopoietic and endothelial lineages derive from a specialized progenitor called a haemangioblast. Three papers in this issue unify the two theories. Both are correct: the haemangioblast does generate haematopoietic cells, but via a haemogenic endothelium intermediate.

Date: 2009
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DOI: 10.1038/nature07760

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