Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

Arun Sreekumar, Laila M. Poisson, Thekkelnaycke M. Rajendiran, Amjad P. Khan, Qi Cao, Jindan Yu, Bharathi Laxman, Rohit Mehra, Robert J. Lonigro, Yong Li, Mukesh K. Nyati, Aarif Ahsan, Shanker Kalyana-Sundaram, Bo Han, Xuhong Cao, Jaeman Byun, Gilbert S. Omenn, Debashis Ghosh, Subramaniam Pennathur, Danny C. Alexander, Alvin Berger, Jeffrey R. Shuster, John T. Wei, Sooryanarayana Varambally, Christopher Beecher and Arul M. Chinnaiyan ()
Additional contact information
Arun Sreekumar: The Michigan Center for Translational Pathology,
Laila M. Poisson: Department of Biostatistics,
Thekkelnaycke M. Rajendiran: The Michigan Center for Translational Pathology,
Amjad P. Khan: The Michigan Center for Translational Pathology,
Qi Cao: The Michigan Center for Translational Pathology,
Jindan Yu: The Michigan Center for Translational Pathology,
Bharathi Laxman: The Michigan Center for Translational Pathology,
Rohit Mehra: The Michigan Center for Translational Pathology,
Robert J. Lonigro: The Michigan Center for Translational Pathology,
Yong Li: The Michigan Center for Translational Pathology,
Mukesh K. Nyati: The Comprehensive Cancer Center,
Aarif Ahsan: Department of Radiation Oncology,
Shanker Kalyana-Sundaram: The Michigan Center for Translational Pathology,
Bo Han: The Michigan Center for Translational Pathology,
Xuhong Cao: The Michigan Center for Translational Pathology,
Jaeman Byun: Department of Internal Medicine,
Gilbert S. Omenn: Center for Computational Medicine and Biology,
Debashis Ghosh: The Comprehensive Cancer Center,
Subramaniam Pennathur: Center for Computational Medicine and Biology,
Danny C. Alexander: Metabolon, Inc. 800 Capitola Drive, Suite 1 Durham, North Carolina 27713, USA
Alvin Berger: Metabolon, Inc. 800 Capitola Drive, Suite 1 Durham, North Carolina 27713, USA
Jeffrey R. Shuster: Metabolon, Inc. 800 Capitola Drive, Suite 1 Durham, North Carolina 27713, USA
John T. Wei: The Comprehensive Cancer Center,
Sooryanarayana Varambally: The Michigan Center for Translational Pathology,
Christopher Beecher: The Michigan Center for Translational Pathology,
Arul M. Chinnaiyan: The Michigan Center for Translational Pathology,

Nature, 2009, vol. 457, issue 7231, 910-914

Abstract: A prostate cancer marker A systematic analysis of metabolites in prostate cancer samples has led to the discovery that sarcosine, an amino acid common in many biological tissues including muscle, is highly elevated in aggressive prostate cancers and detectable in the urine of men with prostate cancer. This makes sarcosine a candidate biomarker for prostate cancer diagnosis. Targeted knockdown of the enzyme that generates sarcosine from glycine attenuated prostate cell invasion in mice, pointing to a possible role in metastasis, and adding the sarcosine pathway to the list of possible therapeutic targets.

Date: 2009
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DOI: 10.1038/nature07762

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