Artificial nanopores that mimic the transport selectivity of the nuclear pore complex

Tijana Jovanovic-Talisman, Jaclyn Tetenbaum-Novatt, Anna Sophia McKenney, Anton Zilman, Reiner Peters, Michael P. Rout and Brian T. Chait ()
Additional contact information
Tijana Jovanovic-Talisman: Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, and,
Jaclyn Tetenbaum-Novatt: Laboratory of Cellular and Structural Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Anna Sophia McKenney: Laboratory of Cellular and Structural Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Anton Zilman: Theoretical Biology and Biophysics Group and Center for Nonlinear Studies, Los Alamos National Laboratory, PO Box 1663, Los Alamos, New Mexico 87545, USA
Reiner Peters: Institute of Medical Physics and Biophysics and Center of Nanotechnology (CeNTech), University of Muenster, Robert-Koch-Strasse 31, 48149 Muenster, Germany
Michael P. Rout: Laboratory of Cellular and Structural Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Brian T. Chait: Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, and,

Nature, 2009, vol. 457, issue 7232, 1023-1027

Abstract: Artificial nanopores: across the nuclear barrier Nuclear pore complexes (NPCs) are the gateways between a cell's nucleus and its cytoplasm and allow only selected macromolecules to cross the nuclear envelope. Based on an elucidation of the architecture and mechanism of this complex, Jovanovic-Talisman et al. have designed and produced an artificial nanopore membrane that mimics its selectivity. The membrane features the two vital elements of the natural complex - a simple passageway and a lining of proteins, phenylalanine-glycine nucleoporins, familiarly known as 'FG-nups'. As in the natural complex, the artificial nanopores allow only transport factors and transport-factor-carrying cargoes that specifically bind to FG-nups, to pass. This work opens the way to an array of nature-inspired nanodevices that can detect and sort molecules of medical and industrial significance.

Date: 2009
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature07600 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:457:y:2009:i:7232:d:10.1038_nature07600

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07600

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().