Bidirectional promoters generate pervasive transcription in yeast

Zhenyu Xu, Wu Wei, Julien Gagneur, Fabiana Perocchi, Sandra Clauder-Münster, Jurgi Camblong, Elisa Guffanti, Françoise Stutz, Wolfgang Huber and Lars M. Steinmetz ()
Additional contact information
Zhenyu Xu: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Wu Wei: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Julien Gagneur: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Fabiana Perocchi: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Sandra Clauder-Münster: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Jurgi Camblong: Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Elisa Guffanti: Sciences III, University of Geneva, 30 Quai E. Ansermet, 1211 Geneva 4, Switzerland
Françoise Stutz: Sciences III, University of Geneva, 30 Quai E. Ansermet, 1211 Geneva 4, Switzerland
Wolfgang Huber: European Molecular Biology Laboratory, European Bioinformatics Institute
Lars M. Steinmetz: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany

Nature, 2009, vol. 457, issue 7232, 1033-1037

Abstract: Small RNAs make the CUT Two papers in this issue reveal the prevalence of cryptic or hidden transcription in the yeast genome. Cryptic unstable transcripts (CUTs) are a major class of RNA polymerase II transcripts in budding yeast and are degraded immediately after being synthesized. They had therefore escaped detection until recently. In the current papers, high-resolution genome analyses reveal that CUTs arise predominantly from promoter regions and in an antisense direction. There is therefore a widespread occurrence of inherently bidirectional promoters in yeast, which hints at a regulatory function for these non-coding transcripts.

Date: 2009
References: Add references at CitEc
Citations: View citations in EconPapers (8)

Downloads: (external link)
https://www.nature.com/articles/nature07728 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:457:y:2009:i:7232:d:10.1038_nature07728

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07728

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().