Widespread bidirectional promoters are the major source of cryptic transcripts in yeast

Helen Neil, Christophe Malabat, Yves d’Aubenton-Carafa, Zhenyu Xu, Lars M. Steinmetz and Alain Jacquier ()
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Helen Neil: Institut Pasteur, Unité de Génétique des Interactions Macromoléculaires, CNRS, URA2171, 75015 Paris, France
Christophe Malabat: Institut Pasteur, Unité de Génétique des Interactions Macromoléculaires, CNRS, URA2171, 75015 Paris, France
Yves d’Aubenton-Carafa: Centre de Génétique Moléculaire, CNRS, Allée de la Terrasse, 91198 Gif-sur-Yvette, France
Zhenyu Xu: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Lars M. Steinmetz: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Alain Jacquier: Institut Pasteur, Unité de Génétique des Interactions Macromoléculaires, CNRS, URA2171, 75015 Paris, France

Nature, 2009, vol. 457, issue 7232, 1038-1042

Abstract: Small RNAs make the CUT Two papers in this issue reveal the prevalence of cryptic or hidden transcription in the yeast genome. Cryptic unstable transcripts (CUTs) are a major class of RNA polymerase II transcripts in budding yeast and are degraded immediately after being synthesized. They had therefore escaped detection until recently. In the current papers, high-resolution genome analyses reveal that CUTs arise predominantly from promoter regions and in an antisense direction. There is therefore a widespread occurrence of inherently bidirectional promoters in yeast, which hints at a regulatory function for these non-coding transcripts.

Date: 2009
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DOI: 10.1038/nature07747

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