Intracortical circuits of pyramidal neurons reflect their long-range axonal targets

Solange P. Brown and Shaul Hestrin ()
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Solange P. Brown: Stanford University School of Medicine, 300 Pasteur Drive, Edwards Building, R314, Stanford, California 94305-5342, USA
Shaul Hestrin: Stanford University School of Medicine, 300 Pasteur Drive, Edwards Building, R314, Stanford, California 94305-5342, USA

Nature, 2009, vol. 457, issue 7233, 1133-1136

Abstract: Cortical mapping: axons' long reach The cerebral cortex is often viewed as a sparsely connected network of neurons. Using quadruple whole-cell recordings, Solange Brown and Shaul Hestrin have now tested for synaptic connections among heterogeneous populations of cortical excitatory cells — pyramidal neurons. Their results reveal highly connected local circuits of neurons, each reflecting the neurons' long-range projections to a different brain region. The findings illustrate a diversity of dense cortical microcircuitry associated with the variety of information streams that produce our repertoire of behaviours and internal states.

Date: 2009
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DOI: 10.1038/nature07658

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