Dendritic encoding of sensory stimuli controlled by deep cortical interneurons

Masanori Murayama, Enrique Pérez-Garci, Thomas Nevian, Tobias Bock, Walter Senn and Matthew E. Larkum ()
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Masanori Murayama: Physiologisches Institut, Universität Bern, Bühlplatz 5, CH-3012 Bern, Switzerland
Enrique Pérez-Garci: Physiologisches Institut, Universität Bern, Bühlplatz 5, CH-3012 Bern, Switzerland
Thomas Nevian: Physiologisches Institut, Universität Bern, Bühlplatz 5, CH-3012 Bern, Switzerland
Tobias Bock: Physiologisches Institut, Universität Bern, Bühlplatz 5, CH-3012 Bern, Switzerland
Walter Senn: Physiologisches Institut, Universität Bern, Bühlplatz 5, CH-3012 Bern, Switzerland
Matthew E. Larkum: Physiologisches Institut, Universität Bern, Bühlplatz 5, CH-3012 Bern, Switzerland

Nature, 2009, vol. 457, issue 7233, 1137-1141

Abstract: Cortical mapping: dendrites run deep Dendrites enhance the computational power of neurons by active processing of synaptic inputs but their activity, particularly in cortex, has been hard to measure. Matthew Larkum and colleagues now use a new fibre-optic method to record dendritic calcium signals in freely moving animals. They show that the strength of a sensory stimulus — a puff or air on a mouse hind leg — is gradually encoded in somatosensory cortex neurons' dendrites, under the control of local inhibitory circuitry. The findings illustrate that the representation of sensory stimuli by cortical neurons cannot be fully described by traditional integrate-and-fire models.

Date: 2009
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DOI: 10.1038/nature07663

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