Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation

Miriam Beer Torchinsky, Johan Garaude, Andrea P. Martin and J. Magarian Blander ()
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Miriam Beer Torchinsky: Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
Johan Garaude: Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
Andrea P. Martin: Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
J. Magarian Blander: Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA

Nature, 2009, vol. 458, issue 7234, 78-82

Abstract: Innate immunity and apoptosis This paper identifies the apoptotic cell engulfment of infected cells as a prominent signal for the induction of TH17 cells, the subset of interleukin 17-producing T helper cells thought to be involved in autoimmunity. This demonstrates that infected apoptotic cells are a critical component of the innate immune signals instructing TH17 differentiation, and point to pathogens particularly adept at triggering apoptosis that might preferentially induce TH17-mediated immunity. Investigation of the pathways of innate recognition of infected apoptotic cells might lead to improved understanding of the causative defects in autoimmunity.

Date: 2009
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DOI: 10.1038/nature07781

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