Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch

Alexander Serganov (), Lili Huang and Dinshaw J. Patel ()
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Alexander Serganov: Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA
Lili Huang: Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA
Dinshaw J. Patel: Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA

Nature, 2009, vol. 458, issue 7235, 233-237

Abstract: A switch for antimicrobials? Riboswitches are structured RNA elements that bind a specific ligand to control expression of the gene to which they are linked. Several bacterial genes involved in the transport and synthesis of riboflavin and related compounds are regulated by a riboswitch that binds flavin mononucleotide (FMN). Serganov et al. report the unusual structure of the metabolite-sensing domain bound to FMN, riboflavin and an antibiotic. The relatively open ligand-binding pocket suggests that antimicrobials based on FMN could be devised.

Date: 2009
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DOI: 10.1038/nature07642

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