Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae

Joseph Schacherer, Joshua A. Shapiro, Douglas M. Ruderfer and Leonid Kruglyak ()
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Joseph Schacherer: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
Joshua A. Shapiro: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
Douglas M. Ruderfer: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
Leonid Kruglyak: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA

Nature, 2009, vol. 458, issue 7236, 342-345

Abstract: Of yeast and man Baker's yeast, Saccharomyces cerevisiae, is one of the best studied model organisms, and has been associated with human activity for thousands of years. Two papers published in the 19 March 2009 issue of Nature provide a picture of its population structure and its relationship with other yeasts. Liti et al. compare genome variation in S. cerevisiae isolates with its closest wild cousin, S. paradoxus, which has never been associated with human activity. They find that variation in S. paradoxus closely follows geographic borders; S. cerevisiae shows less differentiation, consistent with opportunities for cross-breeding, rather than a few distinct domestication events, as the main human influence. Schacherer et al. compare 63 S. cerevisiae isolates from different ecological niches and geographic locations. They find evidence for genetic differentiation of three distinct subgroups based on where the strains were isolated: from vineyards, sake and related fermentations and lab strains. Their data support the hypothesis that these three groups represent separate domestication events, and that S. cerevisiae as a whole is not domesticated.

Date: 2009
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DOI: 10.1038/nature07670

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