Antiviral immunity in Drosophila requires systemic RNA interference spread

Maria-Carla Saleh, Michel Tassetto, Ronald P. van Rij, Bertsy Goic, Valérie Gausson, Bassam Berry, Caroline Jacquier, Christophe Antoniewski and Raul Andino ()
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Maria-Carla Saleh: University of California, San Francisco 94122-2280, USA
Michel Tassetto: University of California, San Francisco 94122-2280, USA
Ronald P. van Rij: University of California, San Francisco 94122-2280, USA
Bertsy Goic: Institut Pasteur, Viruses and RNA interference, F-75015 Paris, France
Valérie Gausson: Institut Pasteur, Viruses and RNA interference, F-75015 Paris, France
Bassam Berry: Institut Pasteur, Drosophila Genetics and Epigenetics; CNRS, URA 2578, F-75015 Paris, France
Caroline Jacquier: Institut Pasteur, Drosophila Genetics and Epigenetics; CNRS, URA 2578, F-75015 Paris, France
Christophe Antoniewski: Institut Pasteur, Drosophila Genetics and Epigenetics; CNRS, URA 2578, F-75015 Paris, France
Raul Andino: University of California, San Francisco 94122-2280, USA

Nature, 2009, vol. 458, issue 7236, 346-350

Abstract: Antiviral RNAi in insects Drosophila and other insects are known to be able to mount a local antiviral defence involving RNA interference (RNAi). It was previously thought that Drosophila is unable to systemically spread an RNAi response, based on observations that endogenously expressed RNA hairpins did not spread from cell to cell. But experiments involving challenge with Sindbis and Drosophila C viruses now show that D. melanogaster can also generate a systemic RNAi response. This suggests that the RNA silencing component of immunity in vertebrates and invertebrates may be more highly conserved than was thought.

Date: 2009
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DOI: 10.1038/nature07712

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