Dynamic expression of epidermal caspase 8 simulates a wound healing response

Pedro Lee, Dai-Jen Lee, Carol Chan, Shih-Wei Chen, Irene Ch’en and Colin Jamora ()
Additional contact information
Pedro Lee: Section of Cell and Developmental Biology, Natural Science Building, Room 6311, 9500 Gilman Drive, MC 0380
Dai-Jen Lee: Section of Cell and Developmental Biology, Natural Science Building, Room 6311, 9500 Gilman Drive, MC 0380
Carol Chan: Section of Cell and Developmental Biology, Natural Science Building, Room 6311, 9500 Gilman Drive, MC 0380
Shih-Wei Chen: Section of Cell and Developmental Biology, Natural Science Building, Room 6311, 9500 Gilman Drive, MC 0380
Irene Ch’en: Section of Molecular Biology, Natural Science Building, Room 5116, 9500 Gilman Drive, MC 0377
Colin Jamora: Section of Cell and Developmental Biology, Natural Science Building, Room 6311, 9500 Gilman Drive, MC 0380

Nature, 2009, vol. 458, issue 7237, 519-523

Abstract: Caspase 8: healing versus neoplasia This paper provides evidence for a role of caspase 8 in skin homeostasis. Loss of epidermal caspase 8, an important mediator of apoptosis, promotes several phases of the wound healing response in mice, including epidermal cell proliferation and inflammation. The findings illustrate how the loss of caspase 8 can have an impact beyond programmed cell death to affect the local microenvironment and elicit processes common to wound repair and many neoplastic skin disorders.

Date: 2009
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature07687 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:458:y:2009:i:7237:d:10.1038_nature07687

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07687

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().