AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Teresa Fernandes-Alnemri, Je-Wook Yu, Pinaki Datta, Jianghong Wu and Emad S. Alnemri ()
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Teresa Fernandes-Alnemri: Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Je-Wook Yu: Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Pinaki Datta: Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Jianghong Wu: Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Emad S. Alnemri: Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA

Nature, 2009, vol. 458, issue 7237, 509-513

Abstract: Innate immunity sensor Cytoplasmic DNA is an important trigger for the innate immune system. The downstream signalling pathways involved in this process have been extensively characterized, but much less is known about the initial step, the recognition of the DNA. Two groups reporting in this issue of Nature have now identified AIM2 (absent in melanoma 2), a member of the interferon-inducible HIN-200 family, as a cytoplasmic DNA sensor. In the presence of DNA, AIM2 oligermerizes and associates with the adapter molecule ASC to activate NF-κB and caspase-1, key components of the inflammasome complex. This highlights the AIM2 inflammasome as a possible target for the treatment of both infections and autoimmune diseases.

Date: 2009
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DOI: 10.1038/nature07710

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