Specific synapses develop preferentially among sister excitatory neurons in the neocortex

Yong-Chun Yu, Ronald S. Bultje, Xiaoqun Wang and Song-Hai Shi ()
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Yong-Chun Yu: Developmental Biology Program, Memorial Sloan Kettering Cancer Centre, 1275 York Avenue
Ronald S. Bultje: Developmental Biology Program, Memorial Sloan Kettering Cancer Centre, 1275 York Avenue
Xiaoqun Wang: Developmental Biology Program, Memorial Sloan Kettering Cancer Centre, 1275 York Avenue
Song-Hai Shi: Developmental Biology Program, Memorial Sloan Kettering Cancer Centre, 1275 York Avenue

Nature, 2009, vol. 458, issue 7237, 501-504

Abstract: Neocortical organization: built with columns The neocortex functions as the executive control centre of the brain in mammals, contributing critically to perception and behaviour. Its structure is complex yet highly organized, though the factors regulating cortical microcircuitry wiring relationships remain poorly understood. A new study in mouse embryos reveals that neurons originating from the same progenitor cell (ontogenetic radial clones) within the developing neocortex are more likely to be synaptically connected to each other than to non-sibling neurons, resulting in the formation of functional columnar microstructures with single-cell resolution.

Date: 2009
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DOI: 10.1038/nature07722

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