AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Veit Hornung (), Andrea Ablasser, Marie Charrel-Dennis, Franz Bauernfeind, Gabor Horvath, Daniel. R. Caffrey, Eicke Latz and Katherine A. Fitzgerald ()
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Veit Hornung: University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Andrea Ablasser: University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Marie Charrel-Dennis: University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Franz Bauernfeind: University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Gabor Horvath: University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Daniel. R. Caffrey: Pfizer, 620 Memorial Drive, Cambridge, Massachusetts 02139, USA
Eicke Latz: University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Katherine A. Fitzgerald: University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA

Nature, 2009, vol. 458, issue 7237, 514-518

Abstract: Innate immunity sensor Cytoplasmic DNA is an important trigger for the innate immune system. The downstream signalling pathways involved in this process have been extensively characterized, but much less is known about the initial step, the recognition of the DNA. Two groups reporting in this issue of Nature have now identified AIM2 (absent in melanoma 2), a member of the interferon-inducible HIN-200 family, as a cytoplasmic DNA sensor. In the presence of DNA, AIM2 oligermerizes and associates with the adapter molecule ASC to activate NF-κB and caspase-1, key components of the inflammasome complex. This highlights the AIM2 inflammasome as a possible target for the treatment of both infections and autoimmune diseases.

Date: 2009
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DOI: 10.1038/nature07725

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