Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells

Daniel A. Lim (), Yin-Cheng Huang, Tomek Swigut, Anika L. Mirick, Jose Manuel Garcia-Verdugo, Joanna Wysocka, Patricia Ernst and Arturo Alvarez-Buylla ()
Additional contact information
Daniel A. Lim: Department of Neurological Surgery,
Yin-Cheng Huang: Department of Neurological Surgery,
Tomek Swigut: Stanford, California 94305, USA
Anika L. Mirick: Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Jose Manuel Garcia-Verdugo: Laboratorio de Neurobiologia Comparada, Instituto Cavanilles, Universidad de Valencia
Joanna Wysocka: Stanford, California 94305, USA
Patricia Ernst: Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Arturo Alvarez-Buylla: Department of Neurological Surgery,

Nature, 2009, vol. 458, issue 7237, 529-533

Abstract: New neurons It is now accepted that the adult brain has the plasticity to grow new cells, but the molecular mechanisms that maintain neurogenesis throughout life in certain brain regions are not known. One major influence on gene expression the structure of chromatin — the complex of nucleotides and protein that make up chromosomes. Lim et al. now show that in the postnatal mouse brain, the chromatin remodelling factor gene Mll1 (mixed lineage leukaemia 1) prompts neural stem cells to form neurons, whereas in the absence of Mll1 the same stem cells produce glial cells, the non-neuronal cells that play a primarily supportive role the nervous system. Mll1 operates in part by activating the downstream gene Dlx2, a key regulator of neurogenesis in the subventricular zone of the brain.

Date: 2009
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature07726 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:458:y:2009:i:7237:d:10.1038_nature07726

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07726

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().