Principles of ubiquitin and SUMO modifications in DNA repair

Steven Bergink and Stefan Jentsch
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Steven Bergink: Max Planck Institute of Biochemistry, Am Klopferspitz 18
Stefan Jentsch: Max Planck Institute of Biochemistry, Am Klopferspitz 18

Nature, 2009, vol. 458, issue 7237, 461-467

Abstract: Abstract With the discovery in the late 1980s that the DNA-repair gene RAD6 encodes a ubiquitin-conjugating enzyme, it became clear that protein modification by ubiquitin conjugation has a much broader significance than had previously been assumed. Now, two decades later, ubiquitin and its cousin SUMO are implicated in a range of human diseases, including breast cancer and Fanconi anaemia, giving fresh momentum to studies focused on the relationships between ubiquitin, SUMO and DNA-repair pathways.

Date: 2009
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DOI: 10.1038/nature07963

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