An unexpected twist in viral capsid maturation

Ilya Gertsman, Lu Gan, Miklos Guttman, Kelly Lee, Jeffrey A. Speir, Robert L. Duda, Roger W. Hendrix, Elizabeth A. Komives and John E. Johnson ()
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Ilya Gertsman: The Scripps Research Institute, La Jolla, California 92037, USA
Lu Gan: The Scripps Research Institute, La Jolla, California 92037, USA
Miklos Guttman: University of California San Diego, La Jolla, California 92037, USA
Kelly Lee: The Scripps Research Institute, La Jolla, California 92037, USA
Jeffrey A. Speir: The Scripps Research Institute, La Jolla, California 92037, USA
Robert L. Duda: University of Pittsburgh, Pennsylvania 15260, USA
Roger W. Hendrix: University of Pittsburgh, Pennsylvania 15260, USA
Elizabeth A. Komives: University of California San Diego, La Jolla, California 92037, USA
John E. Johnson: The Scripps Research Institute, La Jolla, California 92037, USA

Nature, 2009, vol. 458, issue 7238, 646-650

Abstract: Viral procapsid structure The lambda-like double-stranded (ds) DNA bacteriophage HK97 is a favourable system for studying viral capsid maturation since it can be assembled in Escherichia coli from the expression of just two viral gene products and maturation is easily triggered and analysed in vitro. Various mature viral capsid structures have been determined but until now no procapsids have been available for a dsDNA virus or bacteriophage. Gertsman et al. now report the high-resolution structure of the HK97 procapsid providing insight into the capsid assembly process leading to infectious virions. The knowledge gained from this structure is relevant for related viruses such as the human herpesvirus.

Date: 2009
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DOI: 10.1038/nature07686

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