Adaptation of HIV-1 to human leukocyte antigen class I

Yuka Kawashima, Katja Pfafferott, John Frater, Philippa Matthews, Rebecca Payne, Marylyn Addo, Hiroyuki Gatanaga, Mamoru Fujiwara, Atsuko Hachiya, Hirokazu Koizumi, Nozomi Kuse, Shinichi Oka, Anna Duda, Andrew Prendergast, Hayley Crawford, Alasdair Leslie, Zabrina Brumme, Chanson Brumme, Todd Allen, Christian Brander, Richard Kaslow, James Tang, Eric Hunter, Susan Allen, Joseph Mulenga, Songee Branch, Tim Roach, Mina John, Simon Mallal, Anthony Ogwu, Roger Shapiro, Julia G. Prado, Sarah Fidler, Jonathan Weber, Oliver G. Pybus, Paul Klenerman, Thumbi Ndung’u, Rodney Phillips, David Heckerman, P. Richard Harrigan, Bruce D. Walker, Masafumi Takiguchi and Philip Goulder ()
Additional contact information
Yuka Kawashima: Divisions of Viral Immunology and,
Katja Pfafferott: Department of Paediatrics,
John Frater: Nuffield Department of Clinical Medicine and,
Philippa Matthews: Department of Paediatrics,
Rebecca Payne: Department of Paediatrics,
Marylyn Addo: Partners AIDS Research Center, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Boston, Massachusetts 02129, USA
Hiroyuki Gatanaga: Infectious Disease, Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan
Mamoru Fujiwara: Divisions of Viral Immunology and,
Atsuko Hachiya: Divisions of Viral Immunology and,
Hirokazu Koizumi: Divisions of Viral Immunology and,
Nozomi Kuse: Divisions of Viral Immunology and,
Shinichi Oka: Infectious Disease, Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan
Anna Duda: Nuffield Department of Clinical Medicine and,
Andrew Prendergast: Department of Paediatrics,
Hayley Crawford: Department of Paediatrics,
Alasdair Leslie: Department of Paediatrics,
Zabrina Brumme: Partners AIDS Research Center, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Boston, Massachusetts 02129, USA
Chanson Brumme: Partners AIDS Research Center, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Boston, Massachusetts 02129, USA
Todd Allen: Partners AIDS Research Center, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Boston, Massachusetts 02129, USA
Christian Brander: Partners AIDS Research Center, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Boston, Massachusetts 02129, USA
Richard Kaslow: University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
James Tang: University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Eric Hunter: Emory University Vaccine Center and Yerkes National Primate Research Center, Atlanta, Georgia 30329, USA
Susan Allen: Zambia Emory HIV Research Project, and the Zambia Blood Transfusion Service
Joseph Mulenga: Zambia Emory HIV Research Project, and the Zambia Blood Transfusion Service
Songee Branch: Ladymeade Reference Unit, University of West Indies
Tim Roach: Ladymeade Reference Unit, University of West Indies
Mina John: Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University
Simon Mallal: Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University
Anthony Ogwu: Botswana-Harvard School of Public Health AIDS Initiative Partnership
Roger Shapiro: Botswana-Harvard School of Public Health AIDS Initiative Partnership
Julia G. Prado: Department of Paediatrics,
Sarah Fidler: Wright Fleming Institute, Imperial College, St Mary’s Hospital, Norfolk Place, Paddington, London W2 1PG, UK
Jonathan Weber: Wright Fleming Institute, Imperial College, St Mary’s Hospital, Norfolk Place, Paddington, London W2 1PG, UK
Oliver G. Pybus: University of Oxford, South Parks Road, Oxford OX1 3SY, UK
Paul Klenerman: Nuffield Department of Clinical Medicine and,
Thumbi Ndung’u: HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal
Rodney Phillips: Nuffield Department of Clinical Medicine and,
David Heckerman: BC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia V6Z 1Y6, Canada
P. Richard Harrigan: Miscrosoft Research, One Microsoft Way, Redmond, Washington 9805, USA
Bruce D. Walker: Partners AIDS Research Center, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Boston, Massachusetts 02129, USA
Masafumi Takiguchi: Divisions of Viral Immunology and,
Philip Goulder: Department of Paediatrics,

Nature, 2009, vol. 458, issue 7238, 641-645

Abstract: HIV a moving target In order to determine whether HIV is adapting to the human leukocyte antigen (HLA) alleles, such as HLA-B*57, B*57 and B*51, that mediate successful control of the virus, viral sequences and HLA types were analysed in more than 500 HIV-infected subjects drawn from North America, the Caribbean, Europe, Africa, Australasia and Asia. The results reveal that HIV is evolving at the population level in response to immune selection pressure. Whilst this does not indicate that HIV is necessarily 'winning' the evolutionary struggle against humans, it does suggest that successful HIV vaccines — like those against influenza — will need to keep pace with a changing immunological landscape.

Date: 2009
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DOI: 10.1038/nature07746

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