FGF signalling during embryo development regulates cilia length in diverse epithelia

Judith M. Neugebauer, Jeffrey D. Amack, Annita G. Peterson, Brent W. Bisgrove and H. Joseph Yost ()
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Judith M. Neugebauer: University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112-5330, USA
Jeffrey D. Amack: University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112-5330, USA
Annita G. Peterson: University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112-5330, USA
Brent W. Bisgrove: University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112-5330, USA
H. Joseph Yost: University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112-5330, USA

Nature, 2009, vol. 458, issue 7238, 651-654

Abstract: FGF signalling and cilia function Neugebauer et al. show that fibroblast growth factor (FGF) signalling regulates cilia length and function in diverse epithelia during zebrafish and Xenopus development. Reducing FGF signalling reduces cilia length and perturbs directional fluid flow required for left–right patterning of the embryo, as well as shorter tethering cilia in organs of the inner ear and kidneys. They propose that some developmental defects and diseases ascribed to FGF signalling are due in part to loss of cilia function.

Date: 2009
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DOI: 10.1038/nature07753

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