EconPapers    
Economics at your fingertips  
 

FGF signalling during embryo development regulates cilia length in diverse epithelia

Judith M. Neugebauer, Jeffrey D. Amack, Annita G. Peterson, Brent W. Bisgrove and H. Joseph Yost ()
Additional contact information
Judith M. Neugebauer: University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112-5330, USA
Jeffrey D. Amack: University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112-5330, USA
Annita G. Peterson: University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112-5330, USA
Brent W. Bisgrove: University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112-5330, USA
H. Joseph Yost: University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112-5330, USA

Nature, 2009, vol. 458, issue 7238, 651-654

Abstract: FGF signalling and cilia function Neugebauer et al. show that fibroblast growth factor (FGF) signalling regulates cilia length and function in diverse epithelia during zebrafish and Xenopus development. Reducing FGF signalling reduces cilia length and perturbs directional fluid flow required for left–right patterning of the embryo, as well as shorter tethering cilia in organs of the inner ear and kidneys. They propose that some developmental defects and diseases ascribed to FGF signalling are due in part to loss of cilia function.

Date: 2009
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature07753 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:458:y:2009:i:7238:d:10.1038_nature07753

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07753

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().

 
Page updated 2025-03-19
Handle: RePEc:nat:nature:v:458:y:2009:i:7238:d:10.1038_nature07753