Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+

Taufiq-Ur-Rahman, Alexander Skupin, Martin Falcke and Colin W. Taylor ()
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Taufiq-Ur-Rahman: Tennis Court Road, Cambridge CB2 1PD, UK
Alexander Skupin: Mathematical Cell Physiology, Max Delbrück Centre for Molecular Medicine, Robert Rössle Str. 10, 13092 Berlin, Germany
Martin Falcke: Mathematical Cell Physiology, Max Delbrück Centre for Molecular Medicine, Robert Rössle Str. 10, 13092 Berlin, Germany
Colin W. Taylor: Tennis Court Road, Cambridge CB2 1PD, UK

Nature, 2009, vol. 458, issue 7238, 655-659

Abstract: InsP3 receptors and channel opening Inositol trisphosphate (InsP3) is a second messenger that triggers release of Ca2+ from intracellular stores through its cognate receptor — a ligand-gated ion channel. This paper shows that InsP3 receptors aggregate in response to InsP3, resulting in a lower probability of channel opening, and that increases in intracellular Ca2+ can effectively relieve this inhibition and enhance the coupling between receptors in a cluster. This mechanism may serve to enhance the sensitivity to changes in intracellular Ca2+.

Date: 2009
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DOI: 10.1038/nature07763

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