Zhou et al. reply

Zhifeng Zhou (), Guanshan Zhu (), Ahmad R. Hariri, Mary-Anne Enoch (), David Scott, Rajita Sinha, Matti Virkkunen, Deborah C. Mash, Robert H. Lipsky (), Xian-Zhang Hu (), Colin A. Hodgkinson (), Ke Xu (), Beata Buzas (), Qiaoping Yuan (), Pei-Hong Shen (), Robert E. Ferrell, Stephen B. Manuck, Sarah M. Brown, Richard L. Hauger, Christian S. Stohler, Jon-Kar Zubieta and David Goldman ()
Additional contact information
Zhifeng Zhou: Laboratory of Neurogenetics, NIAAA, NIH
Guanshan Zhu: Laboratory of Neurogenetics, NIAAA, NIH
Ahmad R. Hariri: Human Genetics, and Psychology, University of Pittsburgh
Mary-Anne Enoch: Laboratory of Neurogenetics, NIAAA, NIH
David Scott: University of Michigan Medical School
Rajita Sinha: Yale University School of Medicine
Matti Virkkunen: University of Helsinki
Deborah C. Mash: University of Miami School of Medicine
Robert H. Lipsky: Laboratory of Neurogenetics, NIAAA, NIH
Xian-Zhang Hu: Laboratory of Neurogenetics, NIAAA, NIH
Colin A. Hodgkinson: Laboratory of Neurogenetics, NIAAA, NIH
Ke Xu: Laboratory of Neurogenetics, NIAAA, NIH
Beata Buzas: Laboratory of Neurogenetics, NIAAA, NIH
Qiaoping Yuan: Laboratory of Neurogenetics, NIAAA, NIH
Pei-Hong Shen: Laboratory of Neurogenetics, NIAAA, NIH
Robert E. Ferrell: Human Genetics, and Psychology, University of Pittsburgh
Stephen B. Manuck: Human Genetics, and Psychology, University of Pittsburgh
Sarah M. Brown: Human Genetics, and Psychology, University of Pittsburgh
Richard L. Hauger: San Diego VA Healthcare System and University of California
Christian S. Stohler: School of Dentistry, University of Maryland
Jon-Kar Zubieta: University of Michigan Medical School
David Goldman: Laboratory of Neurogenetics, NIAAA, NIH

Nature, 2009, vol. 458, issue 7238, E7-E7

Abstract: Abstract Replying to: C. H. Cotton, J. Flint & T. G. Campbell Nature 458, 10.1038/nature07927 (2009) The inability of Cotton et al. 1 to detect an effect of a functional haplotype (and locus) of neuropeptide Y (NPY), a stress regulatory neuropeptide, on neuroticism is interesting. Although it is important to measure effects of functional loci on complex behaviours, the strength of our study2, and primary basis of its conclusions, was the larger and convergent effects of NPY on intermediate phenotypes, including regional brain responses to emotional stimuli and pain, and brain NPY messenger RNA and plasma NPY levels. Eysenck Neuroticism is a trait that we did not directly investigate. We reported modest association of NPY with two Harm Avoidance subscales from the Tridimensional Personality Questionnaire. Association of NPY with the complex trait of anxiety, especially when measured differently, is not the first place we would look to validate our results.

Date: 2009
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DOI: 10.1038/nature07928

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