Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

Johannes F. Scheid, Hugo Mouquet, Niklas Feldhahn, Michael S. Seaman, Klara Velinzon, John Pietzsch, Rene G. Ott, Robert M. Anthony, Henry Zebroski, Arlene Hurley, Adhuna Phogat, Bimal Chakrabarti, Yuxing Li, Mark Connors, Florencia Pereyra, Bruce D. Walker, Hedda Wardemann, David Ho, Richard T. Wyatt, John R. Mascola, Jeffrey V. Ravetch and Michel C. Nussenzweig ()
Additional contact information
Johannes F. Scheid: Laboratory of Molecular Immunology,
Hugo Mouquet: Laboratory of Molecular Immunology,
Niklas Feldhahn: Laboratory of Molecular Immunology,
Michael S. Seaman: Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Klara Velinzon: Laboratory of Molecular Immunology,
John Pietzsch: Laboratory of Molecular Immunology,
Rene G. Ott: Laboratory of Molecular Genetics and Immunology,
Robert M. Anthony: Laboratory of Molecular Genetics and Immunology,
Henry Zebroski: Proteomics Resource Center,
Arlene Hurley: Rockefeller University Hospital, and,
Adhuna Phogat: Vaccine Research Center, and,
Bimal Chakrabarti: Vaccine Research Center, and,
Yuxing Li: Vaccine Research Center, and,
Mark Connors: Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892, USA
Florencia Pereyra: Partners AIDS Research Center, Mass General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Bruce D. Walker: Partners AIDS Research Center, Mass General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Hedda Wardemann: Max Planck Institute for Infection Biology
David Ho: Aaron Diamond Aids Research Center
Richard T. Wyatt: Vaccine Research Center, and,
John R. Mascola: Vaccine Research Center, and,
Jeffrey V. Ravetch: Laboratory of Molecular Genetics and Immunology,
Michel C. Nussenzweig: Laboratory of Molecular Immunology,

Nature, 2009, vol. 458, issue 7238, 636-640

Abstract: Multiple antibodies fight HIV Serologic memory is an important factor in long-term vaccine efficacy, but there is little understanding of the antibodies produced by memory B cells in individuals infected with important human pathogens such as HIV. To examine the memory antibody response to HIV, Scheid et al. cloned more than 500 antibodies from HIV-specific memory B cells from six HIV-infected patients with high serum titres of broadly neutralizing antibodies. The B-cell memory response to HIV in these patients was composed of up to 50 independent expanded B clones expressing a heterogeneous collection of antibodies to different viral epitopes, several of which may be important for broad HIV neutralization and effective vaccination.

Date: 2009
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DOI: 10.1038/nature07930

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