Association of reactive oxygen species levels and radioresistance in cancer stem cells

Maximilian Diehn, Robert W. Cho, Neethan A. Lobo, Tomer Kalisky, Mary Jo Dorie, Angela N. Kulp, Dalong Qian, Jessica S. Lam, Laurie E. Ailles, Manzhi Wong, Benzion Joshua, Michael J. Kaplan, Irene Wapnir, Frederick M. Dirbas, George Somlo, Carlos Garberoglio, Benjamin Paz, Jeannie Shen, Sean K. Lau, Stephen R. Quake, J. Martin Brown, Irving L. Weissman and Michael F. Clarke ()
Additional contact information
Maximilian Diehn: Department of Radiation Oncology,
Robert W. Cho: Stanford Institute for Stem Cell Biology and Regenerative Medicine,
Neethan A. Lobo: Stanford Institute for Stem Cell Biology and Regenerative Medicine,
Tomer Kalisky: Stanford University, Stanford, California 94305, USA
Mary Jo Dorie: Department of Radiation Oncology,
Angela N. Kulp: Stanford Institute for Stem Cell Biology and Regenerative Medicine,
Dalong Qian: Stanford Institute for Stem Cell Biology and Regenerative Medicine,
Jessica S. Lam: Stanford Institute for Stem Cell Biology and Regenerative Medicine,
Laurie E. Ailles: Stanford Institute for Stem Cell Biology and Regenerative Medicine,
Manzhi Wong: Stanford Institute for Stem Cell Biology and Regenerative Medicine,
Benzion Joshua: Department of Otolaryngology—Head and Neck Surgery,
Michael J. Kaplan: Department of Otolaryngology—Head and Neck Surgery,
Irene Wapnir: Department of Surgery,
Frederick M. Dirbas: Department of Surgery,
George Somlo: Department of Medical Oncology and Therapeutics Research,
Carlos Garberoglio: Department of Surgery,
Benjamin Paz: Department of Surgery,
Jeannie Shen: Department of Surgery,
Sean K. Lau: City of Hope National Medical Center, Duarte, California, California 91010, USA
Stephen R. Quake: Stanford University, Stanford, California 94305, USA
J. Martin Brown: Department of Radiation Oncology,
Irving L. Weissman: Stanford Institute for Stem Cell Biology and Regenerative Medicine,
Michael F. Clarke: Stanford Institute for Stem Cell Biology and Regenerative Medicine,

Nature, 2009, vol. 458, issue 7239, 780-783

Abstract: Reactive oxygen: role in tumour radiation resistance Michael Clarke and colleagues find that cancer stem cell in breast tumours have lower levels of reactive oxygen species (ROS) than the rest of the tumour cells. This property renders cancer stem cells less sensitive to radiation therapy, which may cause radio resistance in breast cancer.

Date: 2009
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DOI: 10.1038/nature07733

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