Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

Chen Zhao, Alan Chen, Catriona H. Jamieson, Mark Fereshteh, Annelie Abrahamsson, Jordan Blum, Hyog Young Kwon, Jynho Kim, John P. Chute, David Rizzieri, Michael Munchhof, Todd VanArsdale, Philip A. Beachy and Tannishtha Reya ()
Additional contact information
Chen Zhao: Department of Pharmacology and Cancer Biology,
Alan Chen: Department of Pharmacology and Cancer Biology,
Catriona H. Jamieson: Stem Cell Research Program, Moores UCSD Cancer Center La Jolla, California 92093, USA
Mark Fereshteh: Department of Pharmacology and Cancer Biology,
Annelie Abrahamsson: Stem Cell Research Program, Moores UCSD Cancer Center La Jolla, California 92093, USA
Jordan Blum: Department of Pharmacology and Cancer Biology,
Hyog Young Kwon: Department of Pharmacology and Cancer Biology,
Jynho Kim: Howard Hughes Medical Institute, Stanford University Medical Center, Stanford, California 94305, USA
John P. Chute: Duke University Medical Center, Durham, North Carolina 27710, USA
David Rizzieri: Duke University Medical Center, Durham, North Carolina 27710, USA
Michael Munchhof: Pfizer Laboratories, Groton, Connecticut 06340, USA
Todd VanArsdale: Pfizer Laboratories, La Jolla, California 92121, USA
Philip A. Beachy: Howard Hughes Medical Institute, Stanford University Medical Center, Stanford, California 94305, USA
Tannishtha Reya: Department of Pharmacology and Cancer Biology,

Nature, 2009, vol. 458, issue 7239, 776-779

Abstract: Hedgehog maintains cancer stem cells Hedgehog signalling has been implicated in a number of cancers. It is now shown to be important in chronic myeloid leukaemias (CML) where it acts to maintain leukaemia stem cells, by regulating the expression of Numb. Importantly, CML stem cells can be depleted when Hedgehog signalling is inhibited, including cells that are resistant to the drug imatinib that is used to treat CML.

Date: 2009
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DOI: 10.1038/nature07737

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