Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

Keisuke Tateishi, Yuki Okada, Eric M. Kallin and Yi Zhang ()
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Keisuke Tateishi: Howard Hughes Medical Institute,
Yuki Okada: Howard Hughes Medical Institute,
Eric M. Kallin: Howard Hughes Medical Institute,
Yi Zhang: Howard Hughes Medical Institute,

Nature, 2009, vol. 458, issue 7239, 757-761

Abstract: Weight control in mice The histone demethylase Jhdm2a/Kdm3a has an important role in nuclear hormone receptor-mediated gene activation and male germ cell development. Tateishi et al., using Jhdm2a-knockout mice, demonstrate that Jhdm2a also regulates expression of metabolic genes such as Ppara and Ucp1. In addition, the obese phenotype of the knockout mice indicates the demethylase is involved in regulation of weight control.

Date: 2009
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DOI: 10.1038/nature07777

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