Identification of a dendritic cell receptor that couples sensing of necrosis to immunity

David Sancho, Olivier P. Joffre, Anna M. Keller, Neil C. Rogers, Dolores Martínez, Patricia Hernanz-Falcón, Ian Rosewell and Caetano Reis e Sousa ()
Additional contact information
David Sancho: Immunobiology Laboratory,
Olivier P. Joffre: Immunobiology Laboratory,
Anna M. Keller: Immunobiology Laboratory,
Neil C. Rogers: Immunobiology Laboratory,
Dolores Martínez: FACS Laboratory, Cancer Research UK, London Research Institute, Lincoln’s Inn Fields Laboratories, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK
Patricia Hernanz-Falcón: Immunobiology Laboratory,
Ian Rosewell: Trangenic Services, Cancer Research UK, Clare Hall Laboratories, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3LD, UK
Caetano Reis e Sousa: Immunobiology Laboratory,

Nature, 2009, vol. 458, issue 7240, 899-903

Abstract: Necrosis recognition linked to immunity Necrotic cell corpses accumulate in tissues as a result of injury or impaired clearance of apoptotic cells, and can induce an inflammatory response that initiates tissue repair. The recently described dendritic C-type lectin receptor CLEC9A, also called DNGR-1, is shown to sense necrotic debris by recognizing a preformed signal that is exposed on necrotic cells, and to mediate cross presentation of dead cell-associated antigens.

Date: 2009
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DOI: 10.1038/nature07750

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