IFNα activates dormant haematopoietic stem cells in vivo

Marieke A. G. Essers, Sandra Offner, William E. Blanco-Bose, Zoe Waibler, Ulrich Kalinke, Michel A. Duchosal and Andreas Trumpp ()
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Marieke A. G. Essers: Deutsches Krebsforschungszentrum (DKFZ), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
Sandra Offner: Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC—Swiss Institute for Experimental Cancer Research, School of Life Science
William E. Blanco-Bose: Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC—Swiss Institute for Experimental Cancer Research, School of Life Science
Zoe Waibler: Paul Ehrlich Institute
Ulrich Kalinke: Paul Ehrlich Institute
Michel A. Duchosal: Service and Central Laboratory of Hematology, CHUV, University Hospitals of Lausanne
Andreas Trumpp: Deutsches Krebsforschungszentrum (DKFZ), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany

Nature, 2009, vol. 458, issue 7240, 904-908

Abstract: Stem cell activation by IFNα Haematopoietic stem cells (HSCs) exist in a dormant state until called upon, in the event of injury, to proliferate in order to quickly repair damaged tissue. This paper shows that in response to treatment of mice with interferon-α (IFNα), HSCs enter an active cell cycle, increase phosphorylation of STAT1 and PKB/Akt, express IFNα target genes and up-regulate stem cell antigen-1 (Sca-1). While chronic activation of the IFNα pathway in HSCs impairs their function, acute IFNa treatment promotes the proliferation of dormant HSCs in vivo. These data may help to clarify the so far unexplained clinical effects of IFNα on leukaemic cells and raise the possibility for novel applications of type I interferons to target cancer stem cells.

Date: 2009
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DOI: 10.1038/nature07815

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