Inactivation of the Fto gene protects from obesity

Julia Fischer, Linda Koch, Christian Emmerling, Jeanette Vierkotten, Thomas Peters, Jens C. Brüning () and Ulrich Rüther ()
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Julia Fischer: Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Universitätsstr. 1, D-40225 Düsseldorf, Germany
Linda Koch: Department of Mouse Genetics and Metabolism, Institute for Genetics and Second Department of Internal Medicine,
Christian Emmerling: Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Universitätsstr. 1, D-40225 Düsseldorf, Germany
Jeanette Vierkotten: Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Universitätsstr. 1, D-40225 Düsseldorf, Germany
Thomas Peters: Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Universitätsstr. 1, D-40225 Düsseldorf, Germany
Jens C. Brüning: Department of Mouse Genetics and Metabolism, Institute for Genetics and Second Department of Internal Medicine,
Ulrich Rüther: Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Universitätsstr. 1, D-40225 Düsseldorf, Germany

Nature, 2009, vol. 458, issue 7240, 894-898

Abstract: Protection from obesity Variations in the human FTO gene have been linked to obesity-related traits in several genome-wide association studies. A functional correlation is now reported between Fto, the equivalent gene in the mouse, and obesity. In Fto-deficient mice there is postnatal growth retardation and a lean phenotype with high energy expenditure and reduced fat accumulation. This suggests that Fto/FTO is involved in homeostasis via the control of energy expenditure.

Date: 2009
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DOI: 10.1038/nature07848

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