Tbx18 and the fate of epicardial progenitors

Vincent M. Christoffels, Thomas Grieskamp, Julia Norden, Mathilda T. M. Mommersteeg, Carsten Rudat and Andreas Kispert
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Vincent M. Christoffels: Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 15 L2-108, 1105 AZ Amsterdam, The Netherlands
Thomas Grieskamp: † Institut für Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. kispert.andreas@mh-hannover.de
Julia Norden: † Institut für Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. kispert.andreas@mh-hannover.de
Mathilda T. M. Mommersteeg: Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 15 L2-108, 1105 AZ Amsterdam, The Netherlands
Carsten Rudat: † Institut für Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. kispert.andreas@mh-hannover.de
Andreas Kispert: † Institut für Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. kispert.andreas@mh-hannover.de

Nature, 2009, vol. 458, issue 7240, E8-E9

Abstract: Abstract Arising from: C.-L. Cai et al. Nature 454, 104–108 (2008)10.1038/nature06969 ; Cai et al. reply Uncovering the origins of myocardial cells is important for understanding and treating heart diseases1,2. Cai et al.3 suggest that Tbx18-expressing epicardium provides a substantial contribution to myocytes in the ventricular septum and the atrial and ventricular walls. Here we show that the T-box transcription factor gene 18 (Tbx18) itself is expressed in the myocardium, showing that their genetic lineage tracing system does not allow conclusions of an epicardial origin of cardiomyocytes in vivo to be drawn.

Date: 2009
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DOI: 10.1038/nature07916

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