Gene regulatory logic of dopamine neuron differentiation

Nuria Flames () and Oliver Hobert ()
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Nuria Flames: Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York 10032, USA
Oliver Hobert: Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York 10032, USA

Nature, 2009, vol. 458, issue 7240, 885-889

Abstract: Directing dopaminergic differentiation Neurons that produce dopamine as a neurotransmitter control a broad variety of brain functions, including motor control, cognition, motivation and pleasure. How precursor cells converge onto the dopaminergic fate across the vast diversity of developmental lineages involved in those functions has been unclear. Nuria Flames and Oliver Hobert now report that the regulatory protein AST-1 is necessary and sufficient to drive and maintain the terminal differentiation of dopaminergic neurons in the nematode C. elegans. As the protein and its terminal differentiation function are strikingly conserved in mice, the results have direct implications for stem-cell replacement strategies in dopamine-related disorders such as Parkinson's disease.

Date: 2009
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DOI: 10.1038/nature07929

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